About Dr. Knox

Spencer C. Knox, MD
Spencer C. Knox, MD

Hello, and welcome to my website!  I am a board certified Gastroenterologist at Borland-Groover Clinic, practicing in Fleming Island (Clay county), Florida. Formally trained by highly experienced and distinguished faculty at University of Massachusetts Medical School-Baystate (Springfield, MA), my three year Gastroenterology fellowship included exposure to a wide array of pathophysiology. Areas of practice encompass esophageal, gastric, small intestine, colorectal, liver, and pancreatic disease processes. Fellowship provided extensive clinic and endoscopic training, including diagnostic and therapeutic upper endoscopy (EGD), colonoscopy, ERCP, and EUS.


Along with providing ample access for patients in the clinic (office) setting, I currently offer the following procedures either in the inpatient or outpatient setting, as clinically indicated:

Diagnostic & therapeutic Upper:

  • Esophagogastroduodenoscopy (EGD) with biopsy
  • Endoscopic hemostasis including bipolar cautery, injection, APC, band ligation, endoclipping, and hemostatic spray technique
  • Endoscopic variceal ligation
  • Foreign body retrieval
  • Endoscopic retrograde cholangiopancreatography (ERCP) – including intraductal brushing and/or biopsy and stenting
  • Endoscopy with fluoroscopic assistance and interpretation
  • Endoscopic radio-frequency ablation
  • Capsule endoscopy
  • Percutaneous endoscopic gastrostomy (PEG) tube placement, exchange, troubleshooting
  • Percutaneous endoscopic gastrostomy with jejunal limb (PEG-J)
  • Direct percutaneous endoscopic jejunostomy (D-PEJ)
  • Endoscopic Ultrasound (EUS) with FNA
  • Esophageal and pyloric stricture dilation

Diagnostic & Therapeutic Lower:

  • Colonoscopy with biopsy
  • Chromoendoscopy for surveillance in patients with IBD
  • Polypectomy, including endoscopic mucosal resection (EMR)
  • Flexible sigmoidoscopy
  • Colonic and small bowel stricture dilation
  • Endoscopic hemostasis including bipolar cautery, injection, APC, band ligation, endoclipping, and hemostatic spray technique
  • Endoscopic luminal stenting
  • Endoscopy with fluoroscopic assistance and interpretation
  • Colonic decompression

Training Pre-Fellowship

Prior to GI Fellowship, I completed Internal Medicine residency training at Orlando Regional Medical Center (Orlando, FL), Orlando Health’s flagship 808-bed tertiary referral center.   I graduated as a member of the Alpha Omega Phi Honor and Service Society from American University of the Caribbean School of Medicine (AUC), earning my MD in December 2014 after completing basic sciences in Sint Maarten (MS1 and MS2), followed by clinical science rotations in New York City, Long Island, and Florida (MS3 and MS4).

In December 2017, I matched into a three-year clinical Gastroenterology fellowship and am trained in both general and advanced endoscopic procedures.  Along with training to become a complete Gastroenterologist, I diagnose and treat gastroesophageal reflux, IBD, celiac disease, colonic pathology, acute and chronic liver disease, biliary disorders, and pancreatic disease. Melding my interest for medicine and technology is important, with the hope that it will improve patient care.

Originally from upstate New York, I graduated in the top 10% of my high school class.  In 2010, I graduated with a bachelors in Psychology at the University of Rochester (Rochester, NY), earning a Distinction in the department, with a minor in Biology.  During the interim year prior to medical school, I worked as an Emergency Room Tech performing phlebotomy, splinting, and assisting nurses/doctors at an upstate New York hospital.  I learned an incredible amount about real world clinical care in a short amount of time.  It is truly a life-long dream of mine to practice medicine.

Proud to showcase my new white coat summer of 2018 before the start of fellowship!

Medical School History

While attending AUC, I was on the Dean’s List for strong academic performance.  I was inducted into Alpha Omega Phi, AUC’s honor and service society.  I was selected by senior faculty to serve as a teaching assistant (TA) for the Department of Anatomy.  As a TA, my duties included preparing mock exams, demonstrating dissection techniques, and teaching in several heavily attended review sessions.  I also served as a “prosector” for the department, demonstrating and teaching more complex forms of human cadaver dissection, including central nervous system dissection.

Additionally, I was selected to serve as an official tutor for the Molecular and Cell Biology course.  Later on, I was a recipient of the Milestone Award for Academic Achievement in Neuroscience, which is presented to students who maintain a GPA of over 90% throughout the third block of Neuroscience.  I was an active member of the American Medical Student Association and volunteered for testing, education, and awareness events for HIV and Alzheimer’s Disease.

Following basic sciences, I earned Superior marks on the majority of my clinical rotations as a third and fourth year medical student.  I matched to my top-choice internal medicine residency program, Orlando Health in downtown Orlando, Florida.

My Blogging Story

Just before medical school in 2011, I stepped into the blogging world with my first website, My.Plasticity.  I covered topics like the “MD vs DO debate” through my Step 1 experience.  My blog’s name morphed on April 8th, 2013 into Medicine Avenue on the Tumblr platform.  Most of my post-med school and pre-residency musings live at [Internal] Medicine.

I enjoy writing in my spare time, using the medium to collect my thoughts. Improving one’s writing is important, particularly in medical education and staying well-rounded.  Advancing one’s practice of medicine is directly related to clinical experience, reading, and writing.

Using this website as a canvas, I hope to convey useful information and meet peers with similar interests.

Hobbies and More

Hiking on our honeymoon in Kauai, October 2016!

During medical school, I fell in love with my (now) wife, Claudia.  For extracurricular activities, I am a technology aficionado, photographer, and enjoy downhill skiing.  I enjoy researching and reading about all categories of cars.  I love traveling and the thought of experiencing novel things in novel environments.  I grew up around boats.  My father granted me the privilege of learning how to drive and enjoy boating.

I feel tremendously fortunate to have the opportunity to learn the core clinical concepts needed to become an independently practicing physician.  To care for and heal people is my passion.  I invite you to join me as I share my plasticity as a human being on the way to becoming a doctor in the 21st century.

– Spencer C. Knox, MD

The good physician treats the disease; the great physician treats the patient who has the disease.

William Osler
Dr. Knox is certified in Internal Medicine (2018) and Gastroenterology (2021)


This website is NOT intended to substitute the judgement of your physician.
Consult your physician for medical advice.
Contents contained herein are the sole opinion of the author, and do not represent the opinion of any other entity.

Unless otherwise noted, all photos are original.